《Scientific Reports》：岩藻多糖可以作为治疗慢性肾炎的潜在药物
2020-06-19
原标题：低分子量岩藻多糖能够保护肾小管上皮细胞免受高蛋白引起的损伤
①蛋白尿是慢性肾炎的重要特征，与肾小球功能障碍有关、肾小管病变及间质损伤密切相关。
②岩藻多糖是来自于褐藻表面黏液的大分子多糖物质，具有多种生理功效，其中包括抗炎症作用。
③本研究在小鼠体内评价了岩藻多糖对保护肾小管上皮细胞免受高蛋白引起的损伤的作用。
④实验结果：岩藻多糖使用量为100mg/kg时能够很好地缓解肾脏损伤及肾功能障碍，血肌酐降低34%，尿素氮降低25%，肌酐清除率提升48%，尿蛋白浓度显著降低。
⑤结论：岩藻多糖可以通过抑制炎症、纤维化、氧化应激和凋亡的途径，保护肾小管上皮细胞免受高蛋白引起的损伤。岩藻多糖可以作为治疗慢性肾炎的潜在药物。
延伸阅读
Scientific Reports. 2016, 6:31759-31768
Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload
Abstract:
Albuminuria is a causative and aggravating factor for progressive renal damage in chronic kidney disease (CKD). The aim of this study was to determine if low molecular weight fucoidan (LMWF) could protect renal function and tubular cells from albumin overload caused injury. Treatment with 10 mg/g bovine serum albumin caused renal dysfunction, morphological changes, and overexpression of inflammation and fbrosis associated proteins in 129S2/Sv mice. LMWF (100 mg/kg) protected against kidney injury and renal dysfunction with decreased blood creatinine by 34% and urea nitrogen by 25%, increased creatinine clearance by 48%, and decreased signifcantly urinary albumin concentration. In vitro proximal tubule epithelial cell (NRK-52E) model showed that LMWF dose-dependently inhibited overexpression of proinflammatory and profbrotic factors, oxidative stress and apoptosis caused by albumin overload. These experimental results indicate that LMWF protects against albumin overload caused renal injury by inhibiting inflammation, fbrosis, oxidative stress and apoptosis, which suggests that LMWF could be a promising candidate drug for preventing CKD.
First Authors:
Yingli Jia
Correspondence:
BaoxueYang
All Authors:
Yingli Jia, Yi Sun, Lin Weng, Yingjie Li, Quanbin Zhang, Hong Zhou & BaoxueYang
