韩国济州大学研究报告：岩藻多糖保护免疫细胞免受放疗影响
原标题：岩藻多糖能保护放疗引起的脾脏细胞受损
①免疫系统对放疗引起的氧化压力非常敏感，因此放疗很容易带来免疫系统副作用，降低人体免疫力；
②在过去几年的研究中，一些植物提取物具有很好的抗氧化及免疫调节作用，被用于放疗补充剂。岩藻多糖是来自于褐藻中的含硫酸基的多糖物质，具有广泛的生物活性，具有很强的抗氧化和提高免疫力的作用；
③在本研究中，岩藻多糖被用于评价缓解放疗引发的免疫系统受损的效果，C57BL/6小鼠被用γ射线照射后，服用岩藻多糖，观察小鼠体内免疫细胞，尤其是脾脏细胞的受损缓解情况；
④实验结果：岩藻多糖不但缓解了正常细胞的DNA受损，而且减少了γ射线引起的免疫细胞大量凋亡的现象；
⑤结论：岩藻多糖能够保护免疫细胞免受放疗影响，可以作为放疗期间的膳食补充剂。
延伸阅读
Korean J Vet Res, 2015, 55(1) : 21-30
Protective effect of Hizikia fusiforme on radiation-induced damage in splenocytes
Abstract:
The immune system is specifically sensitive to oxidative stress induced by ionizing radiation because of its rapid proliferative activity. For this reason, an instructive immune system is one of the best ways to minimize side effects, such immunodeficiency, of gamma radiation. Over the past few decades, several natural plants with antioxidant and immunomodulatory properties have been identified as adjuncts for nontoxic and successful radiotherapy. Hizikia fusiforme extract (HFE) containing plentiful dietary fiber and fucoidan is known for its instructive antioxidant capacity, immunomodulation abilities, and immune activation. In this study, we determined whether HFE protects radiosensitive immune cells from gamma radiation-induced damage. C57BL/6 mice were irradiated with gamma-ray. The effect of HFE on the ionizing radiation damage of immune cells was then evaluated with an MTT assay, 3Hthymidine incorporation assay, and PI staining. We found that HFE stimulated the proliferation of gamma-ray irradiated immune cells without cytotoxic effects. We also observed that HFE not only decreased DNA damage but also reduced gamma radiation-induced apoptosis of the immune cells. Our results suggest that HFE can protect immune cells from gamma-ray damage and may serve as an effective, non-toxic radioprotective agent.
First Authors:
Areum Kim
Correspondence:
Youngheun Jee
All Authors:
Areum Kim, So Jin Bing, Jinhee Cho, Ginnae Ahn, Ji-Hyeok Lee, You-Jin Jeon, Byung-Gul Lee, Youngheun Jee
2015-03-19 Article
