岩藻多糖抗胃溃疡的生物活性评价研究
原标题：岩藻多糖作为小鼠抗胃溃疡的生物活性评价研究
①本研究岩藻多糖提取物的组成为：含水量3.11%，尿酸556ppm，硫酸盐0.12ppm，总碳水化合物1648ppm。
②根据体内试验结果显示，使用浓度为100ppm的岩藻多糖具有防止胃溃疡的作用。岩藻糖能使胃粘膜分层，所以不会损伤胃组织的内层。
③胃粘液是一种糖蛋白，有两种作用：一是润滑食物团，以促进其在胃内运动。二是在胃腔内上皮细胞上形成保护层。这一保护层是一种防御机制，胃可以抵抗自身的赖氨酸蛋白酶的消化，并通过碳酸氢盐从下面的粘膜分泌到表层。
④本研究结果表明，根据100 ppm岩藻多糖对小鼠的组织病理学检查，给予阿司匹林400 mg/kg后，岩藻多糖可有效抑制胃溃疡刺激。岩藻多糖与胃粘膜粘液层的增加有关。
延伸阅读：
Evaluation of fucoidan bioactivity as antigastric ulcers in mice
ABSTRACT: Fucoidan is a polysaccharide compounds containing sulfate group. Fucoidan is found in brown seaweed. In this study,we assess fucoidan activity extracted from brown seaweed Sargassum crassifolium origin from Binuangeun, Banten. Fucoidan extract was tested in mice in vivo. Observations were carried out during 16 days the control (without fucoidan) and fucoidan treatment. Fucoidan were given in various concentration of 100, 200, 300, 400 ppm. On the 14th day, aspirin was given to mice with pre-treated fucoidan 400 ppm as gastric ulcer induction. The fucoidan extracts compositions showed: water content 3.11%, uronic acid 556 ppm, 0.12 ppm sulfate and 1648 ppm total carbohydrate. Results from histopathology assay in mice tissue stomach showed that 100 ppm of fucoidan can inhibit gastric ulcers caused by 400 ppm aspirin irritation. Fucoidan was associated with an increase in the mucus layer in the gastric mucosa.
KEYWORDS: fucoidan, induced-gastric ulcer, irritation, aspirin, bioactivity
All Authors:
Ellya Sinurat, Dan Rosmawaty
