日本学者发表临床研究报告：岩藻多糖可缓解胃癌化疗副作用
原标题：岩藻多糖作为膳食补充剂对晚期不可切除胃癌患者化疗的作用
①对于晚期不可切除胃癌患者，S-1联合顺铂治疗成为一种标准的方案，然而，很多患者由于无法承受该方案的副作用而无法继续进行治疗；
②岩藻多糖是来自于褐藻中的含硫酸基的多糖物质，具有广泛的生物活性，本文研究了岩藻多糖对化疗药物毒性等副作用的影响；
③24位晚期不可切除的胃癌患者被分成两组，岩藻多糖治疗组（n=12）和对照组（n=12）；
④实验结果显示，岩藻多糖能够控制化疗期间疲劳的发生、保持良好营养状态及延长化疗的周期，最终结果表明岩藻多糖治疗组的患者生存期比对照组长；
⑤结论：岩藻多糖应该被作为胃癌患者的膳食补充剂，减少患者化疗的副作用，延长生存期。
延伸阅读
Journal of Cancer Therapy, 2015, 6, 1020-1026
Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer
Abstract:
In Japan, S-1 plus cisplatin has become a standard regimen for the treatment of unresectable advanced gastric cancer; however, many patients are unable to continue effective chemotherapy because of the regimen’s severe side effects. Thus, control of drug toxicity is key to prolonging patient survival. Fucoidan is a major sulfated polysaccharide found in brown seaweeds and has a wide range of biological activities. In the present study, we analyzed the effect of fucoidan on suppressing the toxicity of chemotherapy drugs. Twenty-four patients with unresectable advanced gastric cancer underwent treatment with S-1 plus cisplatin and were randomly allocated into a fucoidan treatment group (n = 12) or a control group without fucoidan treatment (n = 12). The study results demonstrated that fucoidan controlled the occurrence of fatigue during chemotherapy and patients could continue chemotherapy for longer time periods by maintaining the patients’ favorable nourishment status. As a result, the survival of patients with fucoidan treatment was longer than that of patients without fucoidan. Thus, fucoidan should be included as a key food supplement for patients with gastrointestinal carcinomas who are suffering from the adverse side effects of chemotherapy.
First Authors:
Masahide Ikeguchi
Correspondence:
Masahide Ikeguchi
All Authors:
Masahide Ikeguchi, Hiroaki Saito, Yasunari Miki, Takayuki Kimura
2015-10-30 Article
