Helicobacter：岩藻多糖改善肠道菌群，缓解黏膜损伤
①岩藻多糖是一种以岩藻糖为主要单糖的多糖，其上经常有硫酸根取代，具有免疫调节、抗肿瘤和胃肠道保护等多种活性；
②环磷酰胺可损伤小鼠的肠道黏膜，从海地瓜中分离岩藻多糖，分析其对损伤的肠道黏膜的作用；
③岩藻多糖可以缓解肠道黏膜损伤，降低炎症因子的表达，增加紧密连接蛋白的表达；
④并增加短链脂肪酸产生细菌（粪球菌属、理研菌属、Butyricicoccus）的丰度，增加粪便中的总短链脂肪酸，上调小肠中的短链脂肪酸受体。
延伸阅读
Cyclophosphamide (cy) is a widely used cancer drug. Many researchers have focused on the prevention and alleviation of its side effects, particularly damage to the intestinal mucosal barrier. In this study, we examined the effects of fucoidan, isolated from Acaudina molpadioides, on mice with intestinal mucosal damage induced by cyclophosphamide. Our results showed that fucoidan intervention could relieve injury such as decreasing inflammation and increasing the expression of tight junction proteins, and 50 kDa fucoidan significantly increased the abundance of short chain fatty acid (SCFA) producer Coprococcus, Rikenella, and Butyricicoccus (p < 0.05, p < 0.001, and p < 0.05, respectively) species within the intestinal mucosa compared with the cyclophosphamide group, as determined by 16S rDNA gene high-throughput sequencing. In addition, SCFAs, particularly propionate, butyrate, and total SCFAs, were increased in the feces, and SCFA receptors were upregulated in the small intestine. The protective effects of fucoidan on cyclophosphamide treatment may be associated with gut microflora, and 50 kDa fucoidan had superior effects. Therefore, fucoidan may have applications as an effective supplement to protect against intestinal mucosal barrier damage during chemotherapy.
