韩国宋春香大学医学院：岩藻多糖能够改善慢性肾病
①慢性肾病(CKD)是心血管和周围血管疾病的重要危险因素，尽管间充质干细胞(MSC)疗法是治疗CKD相关缺血性疾病的一种有前途的方式，但是病理条件导致间充质干细胞的存活率和增殖分化能力很低；
②岩藻多糖能够增加间充质干细胞的增殖分化能力，促进周期蛋白的表达，包括细胞周期蛋白E、CDK2及CDK4等；
③在慢性肾病小鼠的缺血后肢移植间充质干细胞后，岩藻多糖能增大间充质干细胞的增殖分化能力，提高血液流动量，提升小鼠保肢比例；
④结论：岩藻多糖可以通过增强间充质干细胞的增殖分化水平来改善慢性肾病引起的局部组织缺血症状。
延伸阅读
Journal of Molecular and Cellular Cardiology 97 (2016) 169–179.
Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease
Abstract:
Chronic kidney disease (CKD) is a significant risk factor for cardiovascular and peripheral vascular disease. Although mesenchymal stem cell (MSC)-based therapy is a promising strategy for treatment of ischemic diseases associated with CKD, the associated pathophysiological conditions lead to low survival and proliferation of transplanted MSCs. To address these limitations, we investigated the effects of fucoidan, a sulfated polysaccharide, on the bioactivity of adipose tissue-derived MSCs and the potential of fucoidan-treated MSCs to improve neovascularization in ischemic tissues of CKD mice. Treatment of MSCs with fucoidan increased their proliferative potential and the expression of cell cycle-associated proteins, such as cyclin E, cyclin dependent kinase (CDK) 2, cyclin D1, and CDK4, via focal adhesion kinase and the phosphatidylinositol-4,5-bisphosphate 3-kinase-Akt axis. Moreover, fucoidan enhanced the immunomodulatory activity of MSCs through the ERK-IDO-1 signal cascade. Fucoidan was found to augment the proliferation, incorporation, and endothelial differentiation of transplanted MSCs at ischemic sites in CKD mice hind limbs. In addition, transplantation of fucoidan-treated MSCs enhanced the ratio of blood flow and limb salvage in CKD mice with hind limb ischemia. To our knowledge, our findings are the first to reveal that fucoidan enhances the bioactivity of MSCs and improves their neovascularization in ischemic injured tissues of CKD. In conclusion, fucoidan-treated MSCs may provide an important pathway toward therapeutic neovascularization in patients with CKD.
First Authors:
Jun Hee Lee
Correspondence:
Sang Hun Lee
All Authors:
Jun Hee Lee, Jung Min Ryu, Yong-Seok Han, Mohammad Farid Zia, Hyog Young Kwon, Hyunjin Noh, Ho Jae Han, Sang Hun Lee
2016-05-20 Article
