《海洋药物》最新研究：岩藻多糖可抑制放射性肺炎
原标题：岩藻多糖通过减少肺部炎症因子抑制放疗引起的肺炎及肺纤维化
①放疗是一种非常重要的肿瘤治疗方式，但是放射性肺炎好肺纤维化是胸部放疗典型的副作用；
②岩藻多糖是来自于褐藻的硫酸酯多糖，具有多种生理功效，其中包括抗炎症作用；
③本研究比较了放射性肺炎小鼠使用与不使用岩藻多糖的效果；
④实验结果：岩藻多糖能够有效地改善小鼠放射性肺炎及肺纤维化，减少嗜中性粒细胞和巨噬细胞在肺部的聚集，同时一些炎症因子，如TIMP-1, CXCL1, MCP-1,和MIP-2的表达也显著下降；
⑤结论：岩藻多糖可以有效减少放疗后肺部炎症因子的产生，抑制放射性肺炎和肺纤维化。
延伸阅读
Mar. Drugs 2018, 16, 392-405.
Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues
Abstract:
Purpose: Radiotherapy is a crucial treatment approach for many types of cancer. Radiation pneumonitis (RP) is one of the major complications in chest irradiation. Fucoidan is a sulfated polysaccharide found mainly in various species of brown seaweed. Recent studies have demonstrated the anti-inflammatory effects of fucoidan. However, no study has reported a well-established prophylactic agent for RP. Therefore, we investigated the effects of fucoidan on RP and radiotherapy (RT)-induced lung fibrosis. Materials and Methods: We compared RP and RT-induced fibrosis in lung tissue specimens obtained from irradiated (10 Gy/shot) C57BL/6 mice with or without fucoidan administration (200 mg/kg/day, oral gavage for 14 days). The expression patterns of cytokines in the pleural fluid were determined using a cytokine array and confirmed through enzyme immunoassays. Results: Fucoidan administration attenuated RP and RT-induced fibrosis in lung tissues. Decreased neutrophil and macrophage accumulation was observed in irradiated lung tissues, and radiation-induced lung fibrosis, as demonstrated by Masson trichrome staining, was attenuated. We investigated the expression patterns of inflammatory cytokines in the irradiated lung pleural fluid through the protein array; results revealed that fucoidan administration changed the expression patterns of inflammatory cytokines in irradiated lung tissues. Furthermore, the expression levels of TIMP-1, CXCL1, MCP-1, MIP-2, and interleukin-1Ra were substantially enhanced in the pleural fluid, but fucoidan administration significantly reduced their expression. Conclusions: Fucoidan changes the expression patterns of inflammatory cytokines, which may consequently attenuate RP and RT-induced lung fibrosis.
First Authors:
Hsin-Hsien Yu
Correspondence:
Szu-Yuan Wu
All Authors:
Hsin-Hsien Yu, Edward Chengchuan KO, Chia-Lun Chang, Kevin Sheng-Po Yuan, Alexander T. H. Wu, Yan-Shen Shan and Szu-Yuan Wu
2018-10-19 Article
