中科院海洋所张全斌研究员：岩藻多糖可改善慢性肾炎
原标题：海带岩藻多糖对慢性肾炎的功效及机理研究
①海带自古以来就是一种药食同源的植物，中国人用它作为治疗肾水肿的传统药物；岩藻多糖是来自于海带表面黏液的重要功效成分，具有多种生理功效，其中包括抗炎症作用；
②本文研究了岩藻多糖对慢性肾炎小鼠的功效及机理，分别从血清尿素氮、血清肌酐、相关酶活等指标进行评价；
④实验结果：岩藻多糖能够有效地降低小鼠体内血清尿素氮、血清肌酐浓度，肾小管和肾间质组织病理学显示岩藻多糖能显著改善慢性肾炎症状；
⑤结论：岩藻多糖可以有效改善慢性肾炎，保护肾脏，是一种潜在的肾脏保护的海洋药物。
延伸阅读
Journal of Ethnopharmacology 139 (2012) 807–813
Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease
Abstract:
Ethnopharmacological relevance: Laminaria japonica is a popular seafood and medicinal plant in China, Chinese people use them as a traditional medicine for curing edema disease, a symptom of kidney diseases.
Materials and methods: The renal protective activity and mechanism of fucoidan derivatives was studied against adenine induced CKD in rats. The fucoidan derivatives were administered at dose of 50 and 150 mg/kg body weight. The serum urea nitrogen (SUN), serum creatinine (SCR) and some enzymic activity were detected.
Results: The SUN and SCR level decreased significantly with fucoidan derivatives administration.
Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan derivatives and the mesangial areas were also greatly reduced. Alterations were observed in the activities/levels of serum enzymic (CAT, GSH-PX) and non-enzymic (GSH) antioxidants, along with high level of malondialdehyde (MDA) in the CKD rats. However, normalized lipid peroxidation and antioxidant defenses occurred with fucoidan derivatives administration.
Conclusion: This study exhibited a new mechanism of fucoidan derivatives on CKD rats, that was the samples could alleviate renal tubules, interstitium and mesangial areas mediated by replacing the electronegative content of the glomerular cells and inhibition of mesangial cell proliferation. The study also proved the mechanism of fucoidan derivatives on the CKD rats had relationship with their antioxidant activities, the samples which could enhance the activity of antioxidant enzymes and reduce the LPO level could alleviate the symptom of CKD.
First Authors:
Jing Wang
Correspondence:
Quanbin Zhang
All Authors:
Jing Wang, Feng Wang, Hou Yun, Hong Zhang, Quanbin Zhang
2011-12-22 Article
