《营养科学杂志》：岩藻多糖具有改善慢性结肠炎的活性
原标题：岩藻多糖对结肠炎病理、炎症因子及肠道菌群的作用
①岩藻多糖（fucoidan）是褐藻来源的以岩藻糖为主要组成单糖的一种硫酸化多糖，研究证明岩藻多糖具有很好地改善胃肠道炎症的活性；
②慢性结肠炎是典型的肠道炎症，近几年发病率持续上升，它的主要症状为便血、腹泻、腹部绞痛、体重减轻、疲劳等；
③患有慢性结肠炎的小猪每天服用240mg/kg的岩藻多糖，持续八周，观察小猪的肠道功能及结肠炎炎病情。
④实验结果：服用240mg/kg岩藻多糖的小鼠腹泻情况得到显著改善，体重得到回升，另外，通过对肠道炎症因子及肠道菌群的检测发现，岩藻多糖有效减少了炎症因子的产生，同时改善肠道菌群。
⑤结论：岩藻多糖具有改善肠道炎症的活性。
延伸阅读
Journal of Nutritional Science, 2016, 5, 1-9.
The effect of algal polysaccharides laminarin and fucoidan on colonic pathology, cytokine gene expression and Enterobacteriaceae in a dextran sodium sulfate-challenged porcine model
Abstract:
The algal polysaccharides laminarin (LAM) and fucoidan (FUC) have potent anti-inflammatory activities in the gastrointestinal tract. Our objective was to examine the impact of prior consumption of LAM and/or FUC on pathology and inflammation following a dextran sodium sulfate (DSS) challenge in pigs. Pigs (n 7/group) were assigned to one of five experimental groups for 56 d. From 49–55 d, distilled water or DSS was administered intragastrically. The experimental groups were: (1) basal diet + distilled water (control); (2) basal diet + DSS (DSS); (3) basal diet + FUC + DSS (FUC + DSS); (4) basal diet + LAM + DSS (LAM + DSS); and (5) basal diet + LAM + FUC + DSS (LAMFUC + DSS). The DSS group had decreased body-weight gain (P < 0·05) and serum xylose (P < 0·05), and increased proximal colon pathology score (P < 0·05), diarrhoeal score (P < 0·001) and colonic Enterobacteriaceae (P < 0·05) relative to the control group. The FUC + DSS (P < 0·01), LAM + DSS (P < 0·05) and LAMFUC + DSS (P < 0·05) groups had improved diarrhoeal score, and the LAMFUC + DSS (P < 0·05) group had improved body weight relative to the DSS group. The FUC + DSS group (P < 0·001), LAM + DSS group (P < 0·05) and LAMFUC + DSS group (P < 0·001) had lower IL-6 mRNA abundance relative to the DSS group. The LAM + DSS group had reduced Enterobacteriaceae in proximal colon digesta relative to the DSS group (P < 0·05). In conclusion, FUC or a combination of FUC and LAM improved body-weight loss, diarrhoeal scores and clinical variables associated with a DSS challenge in pigs, in tandem with a reduction in colonic IL-6 mRNA abundance.
First Authors:
C. J. O’Shea
Correspondence:
T. Sweeney
All Authors:
C. J. O’Shea, J. V. O’Doherty, J. J. Callanan, D. Doyle, K. Thornton and T. Sweeney
2016-01-11 Article
