《海洋药物》：岩藻多糖具有强大的免疫增强活性
原标题：来自巨藻的岩藻多糖具有强大的免疫调节作用
①岩藻多糖（fucoidan）是褐藻来源的以岩藻糖为主要组成单糖的一种硫酸化多糖，研究证明岩藻多糖具有多种免疫调节作用，如活化树突细胞（DC）、自然杀伤细胞（NK）、T细胞等，具有抗病毒抗肿瘤活性；
②本研究评价了来自不同褐藻的岩藻多糖的免疫增强作用，包括泡叶藻(A. nodosum)、巨藻(M. pyrifera)、裙带菜(U. pinnatifida)、墨角藻(F. vesiculosus)；
③实验结果：巨藻和裙带菜中的岩藻多糖在较低浓度下就具有很强的延迟中性粒细胞凋亡的作用，巨藻岩藻多糖对NK细胞的活化作用最强，同时激活脾脏DC细胞和T细胞的效果最好。
⑤结论：岩藻多糖具有很强的免疫增强活性，其中巨藻岩藻多糖免疫活化能力最强。
延伸阅读
Mar. Drugs 2015, 13, 1084-1104
Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans
Abstract:
Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs), natural killer (NK) cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of fucoidan from different seaweed extracts has not been thoroughly analyzed and compared. We analyzed fucoidans obtained from Ascophyllum nodosum (A. nodosum), Macrocystis pyrifera (M. pyrifera), Undaria pinnatifida (U. pinnatifida) and Fucus vesiculosus (F. vesiculosus) for their effect on the apoptosis of human neutrophils, activation of mouse NK cells, maturation of spleen DCs, proliferation and activation of T cells, and the adjuvant effect in vivo. Fucoidans from M. pyrifera and U. pinnatifida strongly delayed human neutrophil apoptosis at low concentration, whereas fucoidans from A. nodosum and F. vesiculosus delayed human neutrophil apoptosis at higher concentration. Moreover, fucoidan from M. pyrifera promoted NK cell activation and cytotoxic activity against YAC-1 cells. In addition, M. pyrifera fucoidan induced the strongest activation of spleen DCs and T cells and ovalbumin (OVA) specific immune responses compared to other fucoidans. These data suggest that fucoidan from M. pyrifera can be potentially useful as a therapeutic agent for infectious diseases, cancer and an effective adjuvant for vaccine.
First Authors:
Wei Zhang
Correspondence:
Jun-O Jin
All Authors:
Wei Zhang, Tatsuya Oda, Qing Yu and Jun-O Jin
2015-02-19 Article
