国防医学院：岩藻多糖可改善肿瘤和化疗引起的骨骼肌萎缩症
原标题：岩藻多糖可改善膀胱癌小鼠肿瘤和化疗引起的骨骼肌萎缩症
①肿瘤恶液质的主要特征是厌食症、骨骼肌萎缩和全身炎症；
②岩藻多糖是来自于褐藻中的含硫酸基的多糖物质，具有广泛的生物活性，包括抗肿瘤和抗炎作用，但岩藻多糖对改善肿瘤和化疗引起的肌肉萎缩的研究尚不明确；
③本研究评价了岩藻多糖对膀胱癌小鼠肿瘤和化疗引起的骨骼肌萎缩的改善效果；
④实验结果显示，相比于化疗对照组，岩藻多糖组的小鼠体重减轻、肌肉萎缩、肠道损伤及功能紊乱等症状都得到明显的缓解；小鼠肌肉中炎症因子（如Myostatin、activin A、FoxO3等）的表达得到显著抑制
⑤结论：岩藻多糖能够显著改善肿瘤恶液质相关的肌肉萎缩症状，可以被作为一种新型缓解肿瘤恶液质的营养补充剂。
延伸阅读
Oncotarget, 2016, 7, 32-42
Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice
Abstract:
Cancer cachexia is characterized by anorexia, skeletal muscle atrophy, and systemic inflammation. Fucoidan extracted from brown algae exhibits antiinflammatory and anticancer activities. However, whether fucoidan ameliorates tumour and chemotherapy-induced muscle atrophy and -related cachectic symptoms remains unknown. Compared with mice with bladder cancer treated with chemotherapy alone (TGC group), those treated with a combination of low molecular weight fucoidan (LMWF) and chemotherapy drugs such as gemcitabine and cisplatin (TGCF) showed a signifcant reduction of body weight loss, muscle atrophy, and intestinal injury and dysfunction. Moreover, myostatin, activin A, and pro-inflammatory cytokine production, FoxO3 expression and activation, NF-κB activation, MuRF-1 and MAFbx/ atrogin-1 expression, and proteasome activity in muscle were signifcantly decreased in the TGCF group compared with the TGC group. In addition, insulin-like growth factor 1 (IGF-1) expression and formation, and IGF-1-regulated mTOR/p70S6k/4EBP-1 protein synthesis signalling were elevated in the TGCF group compared with the TGC group. Taken together, these results suggest that LMWF is a potential agent for preventing cancer cachexia-associated muscle atrophy during chemotherapy. Furthermore, the benefcial effect of LMWF may be attributed to suppressing NF-κBevoked inflammation, myostatin and activin A production, and subsequent muscle proteolysis, and enhancing IGF-1-dependent protein synthesis.
First Authors:
Meng-Chuan Chen
Correspondence:
Tz-Chong Chou
All Authors:
Meng-Chuan Chen, Wen-Lin Hsu, Pa-An Hwang, Yen-Lin Chen, Tz-Chong Chou
2016-06-13 Article
