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《中国食品学报》岩藻多糖对急性酒精性胃黏膜损伤的保护作用
发表时间:2020-06-19         作者:岩藻多糖         来源:《中国食品学报》        
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目的:研究岩藻多糖对急性酒精性损伤模型大鼠胃黏膜的保护作用,为胃黏膜保护类功能食品开发提供科学依据。

方法:将60只SD大鼠随机分成空白对照组、模型组、海藻多糖各剂量组【0.083,0.167,0.334 g/(kgBW)】、阳性对照组【(甲氰咪胍,0.8 g/(kg BW)】,每组各10只。采用酒精灌胃致胃黏膜损伤模型。给予岩藻多糖30d后,观察胃黏膜组织的大体和病理组织改变,测定胃组织前列腺素E2含量、丙二醛含量、NO含量及超氧化歧化酶活力。

结果:岩藻多糖能明显改善胃黏膜组织损伤情况,降低损伤积分(P<0.05),提高酒精性损伤抑制率;在高剂量组能提高大鼠胃组织氧化歧化酶活力(P<0.05);各剂量组均能提高大鼠胃组织前列腺素E2含量(P<O.01)和NO含量(P<0.05),降低大鼠胃组织丙二醛含量(P<0.05)。 

结论:岩藻多糖对大鼠急性酒精性胃粘膜损伤具有一定保护作用,其机制可能与增强胃黏膜保护因子,提高抗氧化和降低脂质过氧化能力有关。

参考文献:
The Protective Effects of Fucoidin on the Ethanol-induced Gastric Mucosal Lesion in Rats
Ruan Yanshuol Zhao Jiangyan2 Li Yanmej3 Zhao Xiaohongz' Liu Chang2 Zhang Yab02
('College of LifeScierzce. Capitcd Normal University. Beijing100048
2Research Institute for Science and Technology of Functiorud Foods, College ofApplied Art.s and Sciences. BeijingUnion
University, Beijing100191
3BeijingGreen Jinke Biological Technology Stock Co. Ltd., Beijin.g100081)
Abstract Objective:The protec.tive effects and mechanism of Fucoidin on the ethanol-incluced gastric mucosal leslon of rats in vivo were mvestigated to supply scientific base for functional development of Fucoidin. 
Methods: 60 SD rats were randomly divided into fucoidin groups (0.083, 0.167, 0.334g/(kg BW 》,negative control group, model group,and positive control group (colloidalCimetidine,0.8 g/(kg BW 》.There were 10 cases in each group. The model of' acute gastric mucosa injurewas induced with 95% acetic acirl.After treated with fucoidin for 30 days,the general ancl palhological integral of gastric mucosa lesion were observed.The levels of PCE2.NO.SOD.MDA were measured as per instructions of'assay kits. 
Results: Fucoidin could significantly reduce che lesion .of gastric mucosal by decreasing damage ingegral (P<0.05)and incre.asing the inhibitory rate of fucoidin on ethanol-induced damage. All close of rucoidins c}oucci raise the levels of PGE2 and NO and decease the levels of MDA incluced by ethanol iri gastric mucosa Lissues oI' raLs.The SOD activity were reduced only in 0.334 g/(kg BW) group of fuc:oiclin.Conclusion: FLu-oiclinshows a prolective Pffect on ethdnol-induced gastric mucosal lesion iri rats and its mechanism may l)e related to che increase of' prc)lec'livPf'ac-mr, anti-oxiclative capaciLy ancl the decrease of lipid pemxidation iii raLs
Keywords gastne murosal ILJsion; fucoidin; ethanol; PCE2; anti-oxiclative index

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