《印度尼西亚胃肠病、肝病和消化内镜杂志》：岩藻多糖对慢性胃炎患者胃粘膜厚度的影响研究
原标题：岩藻多糖对慢性胃炎患者胃粘膜厚度的影响作用
①胃炎是生活中最常见的健康问题，慢性胃炎常伴有消化不良，胃酸等症状。胃粘液附着在粘膜表面，是胃粘膜的重要防御机制之一，影响着胃粘膜的厚度。粘液是一种含有硫酸盐的多糖，能通过黏膜表面的蛋白与离子结合从而具有抗消化活性。
②岩藻多糖是来自于褐藻中的含硫酸基的多糖物质，具有广泛的生物活性。口服岩藻多糖对治疗和预防胃疾病均有效，可以缓解胃炎及胃溃疡。
③结论：岩藻多糖可增加慢性胃炎患者胃黏膜粘液厚度。
延伸阅读
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 133, 2011, 79-84.
Influence of Fucoidan in Mucus Thickness of Gastric Mucosa in Patients with Chronic Gastritis
ABSTRACT
Background: Chronic gastritis is commonly found with complains of dyspepsia, which may decrease work productivity. Imbalance between agressive and defensive factors is the cause of chronic gastritis. Therapy is mostly directed to the agressive factors, particularly gastric acid and very few studies are directed on defensive factors. Mucus is the frst defense mechanism of gastric mucosa. Fucoidan is a phytopharmaca, which is thought to increase the thickness of gastric mucosa. The objective of this study was to know the thickness of gastric mucosa in patients with chronic gastritis and to evaluate the effect of fucoidan to the gastric mucosa thickness in patients with chronic gastritis.
Method: In this double-blinded randomized clinical trial study, 41 patients in the Endoscopy Unit Cipto Mangunkusumo Hospital between October 2009 and October 2010 were enrolled consecutively. Selected patients were divided into 2 groups: a group was given fucoidan and another group was given placebo. Statistical analysis was done using T-test.
Results: Of 41 chronic gastritis patients, only 34 patients completed this study. There was difference of mucus thickness of gastric mucosa in patients with chronic gastritis; in the antrum 42.59 µm (± 8.67) and in the corpus 44.28 µm (± 9.64). This study also showed that fucoidan administration increased the mucus thickness in the antrum by 7.42 µm and in the corpus by 7.74 µm compared to placebo signifcantly.
Conclusion: Fucoidan increased the mucus thickness of gastric mucosa in patients with chronic gastritis.
Keywords: mucus thickness, chronic gastritis, fucoidan
All Authors:
Kaka Renaldi*, Marcellus Simadibrata*, Ari Fahrial Syam*,
Abdul Aziz Rani*, Ening Krisnuhoni**
