原标题：岩藻多糖通过抑制VEGF和MMP抑制肺癌细胞在小鼠体内转移

①岩藻多糖是一种含硫酸基的多糖，广泛存在于褐藻中，具有很好的抗癌功效，能引起肝癌、乳腺癌、结肠癌细胞的凋亡，但是岩藻多糖抑制癌细胞转移的机理研究尚不明确；

②本文以Lewis肺癌小鼠为模型，研究了岩藻多糖对肿瘤症状、肿瘤发展及转移的作用；

③岩藻多糖能够改善小鼠肿瘤症状，包括体重降低、肺部结节等；

④岩藻多糖通过抑制血管内皮生长因子（VEGF）和金属基质蛋白酶（MMP）的表达，从而抑制肺癌细胞在小鼠体内的转移。

结论：岩藻多糖可以作为抑制癌细胞转移的潜在药物。

延伸阅读

Mar. Drugs 2015, 13, 1882-1900

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

Abstract:

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through downregulating metastatic factors VEGF and MMPs.

First Authors:

Tse-Hung Huang, Yi-Han Chiu

Correspondence:

Kuang-Hung Hs, Chang-Jer Wu

All Authors:

Tse-Hung Huang, Yi-Han Chiu, Yi-Lin Chan, Ya-Huang Chiu, Hang Wang, Kuo-Chin Huang, Tsung-Lin Li, Kuang-Hung Hsu and Chang-Jer Wu